DNA Vectors
Vector Biolabs pre-synthesized DNA vector
Protein tyrosine phosphatase non-receptor type 1 Adenovirus (Ad-PTP1B)
Vector Biolabs Homeodomain interacting protein kinase 2 Adenovirus (Ad-HIPK2)
The homeodomain-interacting protein kinase (HIPK) family includes three members, HIPK1, HIPK2, and HIPK3. Each family member contains a conserved protein kinase domain as well as a separate domain, which interacts with homeoproteins. HIPK2 appears to act as a corepressor of homeodomain transcription factors, such as NK-3. Also, HIPK2 is regulated by ubiquitin-like modification via the covalent binding of SUMO-1. Subsequently, it is directed to nuclear bodies in vitro.
Vector Biolabs complement component 1, q subcomponent, beta Adenovirus (Ad-C1q(beta))
The complement component proteins, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R, and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. Adipsin, also designated complement factor D, is a serine protease that cleaves complement factor B and may be involved in obesity. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the serum complement system.
Vector Biolabs Myeloid differentiation primary response gene (88) Adenovirus (Ad-Myd88)
Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NFkB and other signaling pathways through the adapter protein MyD88. MyD88 functions as an adapter protein in the association of IL-1 receptor associated kinase (IRAK) with the IL-1 receptor. MyD88 contains a characteristic N-terminal death domain, which is essential for NF-kB activation, and an adjacent Toll/Il-1R homology domain (TIR domain), which is responsible for signal transduction. Mal (MyD88 adapter-like, also designated TIR domain-containing adapter protein (TIRAP), wyatt, or TLR-4 adaptor protein) is a cytoplasmic TIR-domain-containing protein that forms homodimers and also heterodimers with MyD88.
Vector Biolabs Baculoviral IAP repeat-containing 2 Adenovirus (Ad-BIRC2)
TRAF-interacting proteins include TANK (also designated I-TRAF), ILP, ML-IAP, XAF1, c-IAP and survivin. TANK binds to the conserved TRAF-C domain common to TRAF1, TRAF2 and TRAF3. ML-IAP, c-IAP1 and c-IAP2 are related to the inhibitor of apoptosis protein (IAP) family of Baculovirus proteins. The c-IAPs associate with TRAF1 and TRAF2 through their N-terminal BIR motif-containing domain. IAP-like protein (ILP) also contains an N-terminal BIR motif-containing domain. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. An additional IAP family member, survivin (also designated TIAP), is expressed in the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindles. Caspase-3 activity increases when a disruption of survivin-microtubule interactions occurs.
Vector Biolabs Baculoviral IAP repeat-containing 3 Adenovirus (Ad-BIRC3)
TRAF-interacting proteins include TANK (also designated I-TRAF), ILP, ML-IAP, XAF1, c-IAP and survivin. TANK binds to the conserved TRAF-C domain common to TRAF1, TRAF2 and TRAF3. ML-IAP, c-IAP1 and c-IAP2 are related to the inhibitor of apoptosis protein (IAP) family of Baculovirus proteins. The c-IAPs associate with TRAF1 and TRAF2 through their N-terminal BIR motif-containing domain. IAP-like protein (ILP) also contains an N-terminal BIR motif-containing domain. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. An additional IAP family member, survivin (also designated TIAP), is expressed in the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindles. Caspase-3 activity increases when a disruption of survivin-microtubule interactions occurs.
